Peripheral tolerance is the body's way of preventing immune attacks on its own tissues outside the thymus. Regulatory T cells, often marked by FOXP3, are the peacekeepers that enforce this, while anergy silences self-reactive cells. FOXP3 mutations break this peace, leading to severe autoimmune disease.
But from my hostel room, reading about these elegant controls, I see the chaos of Kolkata's streets—a system that should fail but somehow works. The textbook says strict regulation prevents disaster, but life here is a glorious, malfunctioning immune response that still survives.
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