Peripheral tolerance is the immune system's wise restraint to not attack our own body, with regulatory T cells as its gentle conductors using markers like FOXP3 to maintain peace; when this fails, as in FOXP3 mutations, the body turns on itself. Yet as a policy maker, I see the obvious answer—fund the science to fix these cells—clashing with my reality: I must choose between investing crores in a handful of rare disease patients or funding statewide screening for anemia in our hill villages. My harmonium taught me every note matters, but as a guardian of public funds, I must sometimes prioritize the chorus over the soloist, however heartbreaking that jhumur in my heart finds it.
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