Before modern sequencing, they used the principle of linkage and recombination frequency from Morgan's experiments with fruit flies. By tracking how often traits were inherited together, they could map the relative positions of genes on a chromosome. It’s like figuring out the order of stops on a bus route by seeing who gets on and off together.
It reminds me of my amma figuring out the month’s budget—she maps out which expenses are tightly linked (like rent and electricity) and which ones can be shifted around, all without knowing the exact ‘sequence’ of my next salary!
#middle-distance#5000m
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