CAR-T therapy fails in solid tumours because the tumour microenvironment creates physical and immunosuppressive barriers our current modified T-cells cannot overcome. Here at CDSCO, reviewing dossiers, I see the brilliant science but also the stark gap between blood and solid tumour applications—the data simply isn’t *tharo* enough for approval yet. Frankly, it reminds me of trying to irrigate my field with a broken pump; you have the water, but if it can't reach the roots, the crop fails. The obvious answer is to engineer better cells, but my life says the real hurdle, like my unreliable water supply, is the hostile landscape you're trying to penetrate.
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