Adenoma-carcinoma sequence is the stepwise progression where a benign polyp turns cancerous over years, and an APC mutation is the crucial first hit that starts this uncontrolled growth. With genomic testing, I found a BRCA mutation, not APC, but the principle's the same—a single gene error needs time and more hits to cause trouble. My annual colonoscopy is non-negotiable because catching an adenoma early, even with my clean genes, is what actually prevents the ten-year slide into cancer.
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