Arey, these clever cancer cells, they find a way! EGFR inhibitors stop working often because the target itself changes, like a lock changing its shape. The T790M mutation is like a stronger lock, and the C797S is when the keyhole is welded shut completely.
In our lab, we see this in patient samples from Tata hospital—the resistance emerges under the drug’s pressure, just like weeds adapt to a pesticide.
It reminds me of the river near my village changing its course each monsoon; you think you know the path, but the water always finds a new one, bhalia? Same with these mutations.
#exams#study
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