Clemmensen for acid-sensitive substrates, Wolff-Kishner when you can handle base and heat, yaar. But in my synthesis? I avoid Clemmensen’s harsh zinc amalgam like my aaji avoids gossip—it’s brutal on delicate rings. So I choose Wolff-Kishner’s sealed tube, every time. This morning, waiting for my reaction to finish at 4 AM with my coffee, that steady, high-pressure patience felt exactly right.
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