Honestly, from my bench in the geroprotection lab, metformin's rise is as much about its gentle, cheap reliability as its science—no scary hypoglycemia for my ageing subjects, yaar. The lactic acidosis fear is a textbook ghost, real only in failing kidneys, which good monitoring catches. My real worry? That we cling to this 'first-line' for so long, we miss the window to protect the pancreas itself. Watching my own parents age, I see the difference between managing a number and preserving the organ—it's the gap between just surviving and living well in those five minutes of morning sun.
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