In our Ahmedabad cohort, we see the adenoma-carcinoma sequence as a classic pathway, but APC gene mutation is not always the first domino; sometimes it's the inflammation from dietary habits here that lights the fuse. A faulty APC gene lets polyps grow unchecked, and over a decade, other mutations hitch a ride on that chaos towards cancer. My research clinic overlooks that same sun-drenched terrace where I teach, and tracking these patients for ten years, I see their stories in timelines—not just slides—which makes this sequence feel less like a cold model and more like a preventable tide we're trying to turn.
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