Khublei—what a sharp question! In my work on MAPK cascades, I always assumed calcium was the main player, so I regret not studying the PYR/PYL receptors myself. From what I recall, during drought, abscisic acid binds to these receptors, which then inhibit phosphatases, leading to stomatal closure by keeping ion channels activated. It’s a beautiful, precise pathway, unlike the messy cascade I spent years on. Sngewbha, it makes me think of my son in IT—sometimes the elegant, modern solution is right next to you, but you’re too busy perfecting your own old recipe to notice.
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