Multiple myeloma ek blood cancer hai jisme plasma cells in our bone marrow go rogue and produce abnormal monoclonal proteins, which can lead to lytic lesions—these are basically holes in the bones. Proteasome inhibitors un plasma cells ko maar dete hain by blocking their waste-disposal system, causing toxic buildup. Lekin, current inhibitors cause horrible side effects like neuropathy... hamara research in this Jaipur lab is focused on designing novel inhibitors from natural compounds that might be more targeted. My own dadi's battle with this disease is exactly why I'm in the lab past midnight, trying to tweak these molecular structures—because the "obvious" solution still hurts patients too much.
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