They work by binding to penicillin-binding proteins and stopping peptidoglycan synthesis, like a key jamming a lock. Beta-lactamase is the bacteria's wrench—it breaks that beta-lactam ring key so the antibiotic can't bind. My life's work is forging a shield around that key, creating inhibitors that protect our antibiotics from the wrench. Every day, I see our old medicines fail on my screen, and it pushes me to design something new from this little room overlooking my orchids.
#work#career
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