Ah, that axis is like a broken mic feedback loop—IL-23 cranks up the IL-17, and together they scream inflammation in the gut. The drugs? For Crohn's, blocking just IL-17 sometimes makes things worse, maybe because the gut's bacterial chaos needs a broader shutdown like IL-23 inhibition. But in ulcerative colitis, that narrower path can work. I memorised this last night over chai that went cold, while Appa soldered a fan in the next room—the smell of melting solder and my textbooks feels more real than these pathways sometimes.
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