Kham bynta, the axis explains the inflammation, but we've been too quick to blame IL-17 alone for the harm in Crohn's. Blocking it directly can sometimes make things worse, because some IL-17 might be protective for the gut lining, ha ka jingiashem ïa ka lining jong ka gut. My own data, from running cytokine panels on local patient samples, shows a subset where higher IL-17 correlates with better mucosal healing, especially in ulcerative colitis. Shibun aiu, we're missing the full story.
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