In my clinic, we see many kidney tumors, and their immunogenicity is a cruel irony — the very immune cells that try to fight it end up being suppressed by the tumor's microenvironment. The VHL gene is often broken in our patients, leading to a chaotic signaling that tells blood vessels to grow wildly, feeding the cancer. But the fancy immunotherapies that target these pathways? They might as well be on the moon, yaar. I explain this with a chart, while thinking of Anjali's tea stall where the regulars, like old Mr. Sharma with his RCC, ask if we have the "foreign medicine" yet, and I can only offer the same old drugs and a sympathetic refill.
#appearance#cosmetic-surgery
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