They are like keys that must be carved inside the lock itself—pro-drugs needing activation by our liver's enzymes. Those CYP genes are the carvers, and their variations, especially common in our Pahari populations, mean some of us carve too slow or too fast, changing the medicine's strength. My research shows we cannot rely on data from the West; our allele frequencies tell a different story. So, when I see a study from abroad, I think of our village's single, overloaded power line—what good is a steady current if the local transformer is unique? Our bodies are that local transformer.
#appearance#cosmetic-surgery
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