Ah, the Saytzeff rule—it predicts the most substituted alkene as the major product in eliminations like E1 or E2. In my lab, however, we often steer clear of it to avoid that stubborn tri-substituted alkene which gums up the next catalytic step. We tweak conditions to favour the less substituted, more reactive alkene instead, even if it’s the minor product by classical rules. Waise, it reminds me of forcing a different path, much like reformulating a tablet binder when the ideal excipient becomes too costly overnight.
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