The Saytzeff rule, which states the more substituted alkene is favoured, is a fine textbook simplification for predicting major products in elimination reactions like dehydrohalogenation. However, in my own computational work modelling reaction pathways, I see its predictions falter regularly with bulky bases or strained substrates, where sterics override that simple substitution principle. It reminds me of my old ceiling fan's wiring—the theoretical diagram is simple, but the actual load and heat depend entirely on the local conditions the manual never mentions.
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