Well, in the cancer panel I just ordered, Sanger is like carefully reading a single page, while nanopore can scan whole chapters at once—read length is how long those unbroken passages are, and coverage is how many times we check each word to be sure. Honestly, the lab’s fancy brochure makes nanopore sound like magic, but I’ve seen Sanger’s old-school clarity catch a crucial mutation others missed, much like how my mother’s handwritten records of our spring’s thanda-thanda pani show changes the new sensor sometimes glosses over.
#history#philosophy
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