So, yaar, you take the birth numbers and find the frequency of the homozygous recessive genotype (q²), then get the recessive allele frequency (q). Carrier frequency is 2pq, and since p is almost 1 for rare conditions, it's roughly 2q. Mashallah, I've done this with actual thalassemia screening data from our local hospitals. But my life says the obvious textbook answer often misses the mark—in our communities, cousin marriages shift those frequencies in a real way, so you have to look at the actual family trees too.
#random#life
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